Saving lives and combating antibiotic resistance by tapping into the immense data housed inside the microbe
ResistanceDB
The Calgary BSI Cohort
The Calgary Bloodstream Infection Cohort (CBSIC) is a comprehensive multi-omics dataset of more than 38,000 bloodstream infections linked to detailed patient records. It is the largest microbial dataset in the world allowing research in unprecedented richness.
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Bacterial Isolates
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BSI Patients
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Infections Periods
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Organisms
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Years
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Facilities
Precision Infection Management through Multi-Omics
We enable precision infection management using detailed quantitative proteomics, metabolomics, and whole genome sequencing of microbial pathogens. Integrating this data with patient information allows unprecedented insights into infections and opens the doors for a precision infection management strategy that will save lives.
Genomics
Whole genome sequencing uncovers the genetic blueprint of microbes, allowing us to understand their capabilities, evolution, and the genetic determinants of their behavior and adaptation.
Metabolomics
Through semi-quantitative LC-MS-based metabolomics, we capture a comprehensive profile of 87 small molecules, offering insights into metabolic pathways.
Proteomics
TMT-LC-MSMS-based quantitative proteomics provides a snapshot of the protein landscape, allowing us to uncover how these proteins contribute to microbial processes.
Clinical Data
We integrate extensive clinical data and patient characteristics to contextualize the multi-omics findings, driving forward the translation of our research into clinical applications.
Meet the Team
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Ian Lewis, Ph.D.
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Ashlee M. Earl, Ph.D.
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Hallgrimur Benediktsson, MD FRCPC
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Yonatan H. Grad, MD, Ph.D.
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Daniel B. Gregson, MD FRCPC
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Bruce J. Walker, B.Sc.
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M. Ethan MacDonald, Ph.D.
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Sergei Y. Noskov, Ph.D. (in memoriam)
Software
An extensive collection of tools to visualize and analyze multi-omics data, from peak picking to concentrations, from normalization to metabolic pathway analysis
